A Large Pseudoautosomal Region on the Sex Chromosomes of the Frog Silurana tropicalis
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Genomics study of the pseudoautosomal region on frog sex chromosomes.
It investigates frog sex chromosomes, not research itself.
Genetics of frog sex chromosomes; organismal biology, not research methods or system.
Abstract
Sex chromosome divergence has been documented across phylogenetically diverse species, with amphibians typically having cytologically nondiverged ("homomorphic") sex chromosomes. With an aim of further characterizing sex chromosome divergence of an amphibian, we used "RAD-tags" and Sanger sequencing to examine sex specificity and heterozygosity in the Western clawed frog Silurana tropicalis (also known as Xenopus tropicalis). Our findings based on approximately 20 million genotype calls and approximately 200 polymerase chain reaction-amplified regions across multiple male and female genomes failed to identify a substantially sized genomic region with genotypic hallmarks of sex chromosome divergence, including in regions known to be tightly linked to the sex-determining region. We also found that expression and molecular evolution of genes linked to the sex-determining region did not differ substantially from genes in other parts of the genome. This suggests that the pseudoautosomal region, where recombination occurs, comprises a large portion of the sex chromosomes of S. tropicalis. These results may in part explain why African clawed frogs have such a high incidence of polyploidization, shed light on why amphibians have a high rate of sex chromosome turnover, and raise questions about why homomorphic sex chromosomes are so prevalent in amphibians.
Stored with the screening record, where it is evidence for the labels above.
The record
- Venue
- Genome Biology and Evolution
- Topic
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- McMaster University
- Funders
- National Institute on Deafness and Other Communication DisordersMedical Research CouncilMinistero dello Sviluppo EconomicoMinisterstvo ZemědělstvíOntario Ministry of Economic Development and InnovationMcMaster UniversityUniverzita Karlova v Praze
- Keywords
- Pseudoautosomal regionBiologyEvolutionary biologyZoologyGeneticsGeneX chromosome
- Has abstract in OpenAlex
- yes