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Record W2122193753 · doi:10.1177/0037549713516691

Hybrid simulation of brain–skull growth

2013· article· en· W2122193753 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueSIMULATION · 2013
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicCraniofacial Disorders and Treatments
Canadian institutionsUniversity of British ColumbiaWestern University
Fundersnot available
KeywordsCraniosynostosisSkullCraniosynostosesAnatomyComputer scienceBiology

Abstract

fetched live from OpenAlex

This paper describes a hybrid model that includes both a standard finite element model and also volume-preserving structural modeling for a clinical application involving skull development in infants, with particular application to craniostosis modeling. To accommodate the growing brain, the skull needs to grow quickly in the first few months of life, and most of the growth of the skull at that time occurs at the sutures. Craniosynostosis, which is a developmental abnormality, occurs when one or more sutures are fused early in life (even in utero) while the skull is growing, resulting in an abnormal skull shape. To study normal brain–skull growth and to develop a model of craniosynostosis, we have developed a hybrid computational model to simulate the relationship between the growing deformable brain and the rigid skull. Our model is composed of the nine segmented skull plates as rigid surfaces, deformable sutures, and a volumetrically controllable deformable brain. The Cranial Index (ratio of biparietal width to fronto-occipital length) is measured during the simulation, showing a characteristic peak during development. Measures of linear growth along each dimension show characteristic increases over time. The hybrid simulation framework shows promise to support further investigations into abnormal skull development. By varying the properties of the sutures in our model, we can now simulate different craniosynostosis models, such as scaphocephaly and trigonocephaly. In this paper, we show results on the evolution of the Cranial Index as calculated using standard landmarks and compare to the normal index, and thereby evaluate our model by comparing it with patient data.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: Simulation or modeling
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.197
Threshold uncertainty score0.290

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.008
GPT teacher head0.259
Teacher spread0.252 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it