Evidence for Network Evolution in an <i>Arabidopsis</i> Interactome Map
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Abstract
Plants have unique features that evolved in response to their environments and ecosystems. A full account of the complex cellular networks that underlie plant-specific functions is still missing. We describe a proteome-wide binary protein-protein interaction map for the interactome network of the plant Arabidopsis thaliana containing about 6200 highly reliable interactions between about 2700 proteins. A global organization of plant biological processes emerges from community analyses of the resulting network, together with large numbers of novel hypothetical functional links between proteins and pathways. We observe a dynamic rewiring of interactions following gene duplication events, providing evidence for a model of evolution acting upon interactome networks. This and future plant interactome maps should facilitate systems approaches to better understand plant biology and improve crops.
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The record
- Venue
- Science
- Topic
- Bioinformatics and Genomic Networks
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- —
- Funders
- National Institute of General Medical SciencesNational Human Genome Research InstituteBiotechnology and Biological Sciences Research CouncilCanada Excellence Research Chairs, Government of CanadaFonds De La Recherche Scientifique - FNRSNational Cancer InstituteNational Institutes of HealthNational Science FoundationJames S. McDonnell FoundationU.S. Department of Agriculture
- Keywords
- InteractomeArabidopsisComputational biologyBiologyComputer scienceGeneGenetics
- Has abstract in OpenAlex
- yes