MAST CELLS AS “TUNABLE” EFFECTOR AND IMMUNOREGULATORY CELLS: Recent Advances
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
Abstract
This review focuses on recent progress in our understanding of how mast cells can contribute to the initiation, development, expression, and regulation of acquired immune responses, both those associated with IgE and those that are apparently expressed independently of this class of Ig. We emphasize findings derived from in vivo studies in mice, particularly those employing genetic approaches to influence mast cell numbers and/or to alter or delete components of pathways that can regulate mast cell development, signaling, or function. We advance the hypothesis that mast cells not only can function as proinflammatory effector cells and drivers of tissue remodeling in established acquired immune responses, but also may contribute to the initiation and regulation of such responses. That is, we propose that mast cells can also function as immunoregulatory cells. Finally, we show that the notion that mast cells have primarily two functional configurations, off (or resting) or on (or activated for extensive mediator release), markedly oversimplifies reality. Instead, we propose that mast cells are "tunable," by both genetic and environmental factors, such that, depending on the circumstances, the cell can be positioned phenotypically to express a wide spectrum of variation in the types, kinetics, and/or magnitude of its secretory functions.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- Annual Review of Immunology
- Topic
- Mast cells and histamine
- Field
- Immunology and Microbiology
- Canadian institutions
- —
- Funders
- National Heart, Lung, and Blood InstituteNational Medical Research CouncilNational Institute of Allergy and Infectious DiseasesNational Health and Medical Research CouncilNatural Sciences and Engineering Research Council of CanadaNational Cancer InstituteNational Institutes of Health
- Keywords
- BiologyEffectorMast cellImmune systemCell biologyProinflammatory cytokineImmunologyImmunoglobulin EMast (botany)InflammationInterleukin 33Function (biology)Cell typeCellCytokineAntibodyInterleukinGenetics
- Has abstract in OpenAlex
- yes