RETRACTED ARTICLE: Coffee component hydroxyl hydroquinone (HHQ) as a putative ligand for PPAR gamma and implications in breast cancer
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Post-publication record
- Nature
- Retraction
- Reason
- Duplication of/in Article;Euphemisms for Duplication;Euphemisms for Plagiarism;Plagiarism of/in Article;
- Date
- 2/14/2022 0:00
- Flagged by OpenAlex?
- Yes
Source: Retraction Watch, joined by DOI. OpenAlex records retraction as is_retracted, a boolean over a state space with at least four values, so it cannot express an expression of concern, a correction or a reinstatement — it reports them as false, which reads as “fine”.
Abstract
BACKGROUND: Coffee contains several compounds that have the potential to influence breast cancer risk and survival. However, epidemiologic data on the relation between coffee compounds and breast cancer survival are sparse and inconsistent. RESULTS: We show that coffee component HHQ has significant apoptotic effect on MDA-MB-231 and MCF-7 cells in vitro, and that ROS generation, change in mitochondrial membrane permeability, upregulation of Bax and Caspase-8 as well as down regulation of PGK1 and PKM2 expression may be important apoptosis-inducing mechanisms. The results suggest that PPARγ ligands may serve as potential therapeutic agents for breast cancer therapy. HHQ was also validated as a ligand for PPARγ by docking procedure. CONCLUSION: This is the first report on the anti-breast cancer (in vitro) activity of HHQ.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- BMC Genomics
- Topic
- Coffee research and impacts
- Field
- Medicine
- Canadian institutions
- University of Saskatchewan
- Funders
- —
- Keywords
- Breast cancerIn vitroApoptosisCancer researchDownregulation and upregulationLigand (biochemistry)BiologyPharmacologyCancerBioinformaticsChemistryBiochemistryReceptorGeneGenetics
- Has abstract in OpenAlex
- yes