Prediction of protein-coding regions in DNA sequences using a model-based approach
Why this work is in the frame
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Bibliographic record
Abstract
Prediction of the protein-coding regions (exons) is one of the central issues of DNA sequence analysis. Most of the existing computational methods exploit the period-3 property of the coding-regions to distinguish exons from noncoding regions (introns). However, the current Discrete Fourier Transform (DFT) based methods are inadequate in predicting short exons. In this paper, we present a model-based exon detection approach using statistically optimal null filter. The proposed method employs a model of the period-3 characteristic to maximize signal-to-noise ratio, and least-squares optimization criteria to rapidly detect the presence of exons in the input DNA sequence. Through examples, it is shown that the proposed method is highly effective as compared to the DFT technique, especially in identifying short exons and successive exons separated by short introns.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it