Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice
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Post-publication record
- Nature
- Retraction
- Reason
- Duplication of/in Image;Falsification/Fabrication of Data;Investigation by Company/Institution;Investigation by Journal/Publisher;Misconduct - Official Investigation(s) and/or Finding(s);Misconduct by Author;Unreliable Results and/or Conclusions;Upgrade/Update of Prior Notice(s);
- Date
- 6/1/2017 0:00
- Flagged by OpenAlex?
- Yes
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Abstract
A complex biologic network regulates kidney perfusion under physiologic conditions. This system is profoundly perturbed following renal ischemia, a leading cause of acute kidney injury (AKI) - a life-threatening condition that frequently complicates the care of hospitalized patients. Therapeutic approaches to prevent and treat AKI are extremely limited. Better understanding of the molecular pathways promoting postischemic reflow could provide new candidate targets for AKI therapeutics. Due to its role in adapting tissues to hypoxia, we hypothesized that extracellular adenosine has a regulatory function in the postischemic control of renal perfusion. Consistent with the notion that equilibrative nucleoside transporters (ENTs) terminate adenosine signaling, we observed that pharmacologic ENT inhibition in mice elevated renal adenosine levels and dampened AKI. Deletion of the ENTs resulted in selective protection in Ent1-/- mice. Comprehensive examination of adenosine receptor-knockout mice exposed to AKI demonstrated that renal protection by ENT inhibitors involves the A2B adenosine receptor. Indeed, crosstalk between renal Ent1 and Adora2b expressed on vascular endothelia effectively prevented a postischemic no-reflow phenomenon. These studies identify ENT1 and adenosine receptors as key to the process of reestablishing renal perfusion following ischemic AKI. If translatable from mice to humans, these data have important therapeutic implications.
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The record
- Venue
- Journal of Clinical Investigation
- Topic
- Adenosine and Purinergic Signaling
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- York University
- Funders
- National Institute of Diabetes and Digestive and Kidney DiseasesNational Heart, Lung, and Blood InstituteUniversity of Colorado DenverNational Cancer InstituteNational Institutes of HealthCrohn's and Colitis FoundationCrohn's and Colitis Foundation of AmericaDeutsche ForschungsgemeinschaftNational Center for Research ResourcesAmerican Heart Association
- Keywords
- NucleosideAcute kidney injuryBlood flowKidneyMedicineRenal blood flowTransporterPharmacologyCardiologyInternal medicineChemistryGeneBiochemistry
- Has abstract in OpenAlex
- yes