Hyaluronan and Homeostasis: A Balancing Act
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
Machine scores (provisional)
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
- Teacher spread
- 0.274 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
The investigation of the functions of hyaluronan, which began with its discovery in the 1930s (1), has evolved slowly. Re-examination of the fascinating and complex biology of hyaluronan is now occurring both as a result of increasing awareness of the key and complex role played by components of the extracellular matrix in the regulation of developmental, physiological, and disease processes and of the relatively recent cloning of many new hyaladherins, synthases, and hyaluronidases. During the coming decades, unraveling the hyaluronan enigma will undoubtedly uncover paradigms that shift our understanding for its roles in the regulation of cell homeostasis and matrix biology.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- Journal of Biological Chemistry
- Topic
- Proteoglycans and glycosaminoglycans research
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- —
- Funders
- Canadian Institutes of Health ResearchNational Cancer InstituteMedical Research CouncilKuopion Yliopistollinen SairaalaAcademy of Finland
- Keywords
- GlycosaminoglycanHyaluronic acidGlucuronic acidMucusChemistryHomeostasisCell biologyDisaccharideBiochemistryIn vivoPolysaccharideBiologyAnatomyGenetics
- Has abstract in OpenAlex
- yes