The functional role of long non-coding RNA in human carcinomas
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Abstract
Long non-coding RNAs (lncRNAs) are emerging as new players in the cancer paradigm demonstrating potential roles in both oncogenic and tumor suppressive pathways. These novel genes are frequently aberrantly expressed in a variety of human cancers, however the biological functions of the vast majority remain unknown. Recently, evidence has begun to accumulate describing the molecular mechanisms by which these RNA species function, providing insight into the functional roles they may play in tumorigenesis. In this review, we highlight the emerging functional role of lncRNAs in human cancer.
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The record
- Venue
- Molecular Cancer
- Topic
- Cancer-related molecular mechanisms research
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- University of British ColumbiaBC Cancer Agency
- Funders
- Congressionally Directed Medical Research ProgramsNational Cancer InstituteCanadian Institutes of Health ResearchU.S. Department of Defense
- Keywords
- BiologyCarcinogenesisLong non-coding RNAComputational biologyRNAGeneFunction (biology)CancerBioinformaticsGenetics
- Has abstract in OpenAlex
- yes