Greenlandic Inuit show genetic signatures of diet and climate adaptation
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A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
Machine scores (provisional)
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- Teacher spread
- 0.232 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
The indigenous people of Greenland, the Inuit, have lived for a long time in the extreme conditions of the Arctic, including low annual temperatures, and with a specialized diet rich in protein and fatty acids, particularly omega-3 polyunsaturated fatty acids (PUFAs). A scan of Inuit genomes for signatures of adaptation revealed signals at several loci, with the strongest signal located in a cluster of fatty acid desaturases that determine PUFA levels. The selected alleles are associated with multiple metabolic and anthropometric phenotypes and have large effect sizes for weight and height, with the effect on height replicated in Europeans. By analyzing membrane lipids, we found that the selected alleles modulate fatty acid composition, which may affect the regulation of growth hormones. Thus, the Inuit have genetic and physiological adaptations to a diet rich in PUFAs.
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The record
- Venue
- Science
- Topic
- Genetic and phenotypic traits in livestock
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- —
- Funders
- Novo Nordisk Foundation Center for Basic Metabolic ResearchNovo Nordisk FondenNational Institutes of HealthKaren Elise Jensens FondLeverhulme TrustNational Human Genome Research InstituteDanmarks Frie ForskningsfondVillum Fonden
- Keywords
- BiologyPolyunsaturated fatty acidAdaptation (eye)GenomeTriglycerideZoologyEvolutionary biologyGeneEcologyGeneticsCholesterolBiochemistryFatty acid
- Has abstract in OpenAlex
- yes