Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
VenueNature Communications · 2015
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicReceptor Mechanisms and Signaling
Canadian institutionsUniversité de Sherbrooke
FundersFP7 Ideas: European Research CouncilLaboratory Directed Research and DevelopmentNational Institute of Neurological Disorders and StrokeNational Institute of Nursing ResearchNational Institute on Deafness and Other Communication DisordersNational Human Genome Research InstituteBiomedical Research CouncilWake Forest School of MedicineNational Heart, Lung, and Blood InstituteKaiser Foundation Research InstituteNational Institutes of HealthDiabetesforeningenH. Lundbeck A/SHjartaverndNovo Nordisk Foundation Center for Basic Metabolic ResearchHarokopio UniversityMedical Research CouncilUppsala UniversitetDeutsche KrebshilfeNHLBI Division of Intramural ResearchNational Institute on AgingHelsefondenNational Center for Research ResourcesNational and Kapodistrian University of AthensStockholms Läns LandstingCentre for Medical Systems BiologyNovo NordiskKarolinska InstitutetTore Nilsons Stiftelse för Medicinsk ForskningHjärt-LungfondenMinistero della SaluteFondazione CariploChief Scientist Office, Scottish Government Health and Social Care DirectorateBritish Heart FoundationBundesministerium für Bildung und ForschungZonMwNational Science FoundationFondation LeducqNational Medical Research CouncilSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungUniversity of GlasgowRussian Foundation for Basic ResearchNederlandse Organisatie voor Wetenschappelijk OnderzoekUniversity of ExeterDiabetes UKNational Eye InstituteNational Institute for Health and Care ResearchSwedish e-Science Research CentreCedars-Sinai Medical CenterScottish GovernmentNational Cancer InstituteLundbeckfondenDonald W. Reynolds FoundationEli Lilly and CompanyUniversity of AlabamaImperial College Healthcare NHS TrustWellcome TrustUniversity of Alabama at BirminghamNational Center for Advancing Translational SciencesUniversità degli Studi di VeronaMagnus Bergvalls StiftelseHjerteforeningenNational Institute on Minority Health and Health DisparitiesAstraZenecaUniversity of AberdeenEuropean CommissionAugustinus FondenCompagnia di San PaoloVetenskapsrådetUniversity of MinnesotaWake Forest UniversityNorthwestern UniversitySanofiImperial College LondonResearch to Prevent BlindnessUniversity of California, San FranciscoGlaxoSmithKlineNational Institute of Diabetes and Digestive and Kidney DiseasesKnut och Alice Wallenbergs StiftelseScottish Funding CouncilStiftelsen för Gamla TjänarinnorErasmus Universiteit RotterdamJohns Hopkins UniversityChinese Society of Clinical OncologyAmgenErasmus Medisch CentrumU.S. Environmental Protection AgencyUniversity of DundeeAndrea and Charles Bronfman Philanthropies
KeywordsExomeType 2 diabetesExome sequencingDiabetes mellitusMedicineGeneticsMutationBioinformaticsEndocrinologyInternal medicineBiologyGene
Abstract
fetched live from OpenAlexFasting glucose and insulin are intermediate traits for type 2 diabetes. Here we explore the role of coding variation on these traits by analysis of variants on the HumanExome BeadChip in 60,564 non-diabetic individuals and in 16,491 T2D cases and 81,877 controls. We identify a novel association of a low-frequency nonsynonymous SNV in GLP1R (A316T; rs10305492; MAF=1.4%) with lower FG (β=-0.09±0.01 mmol l(-1), P=3.4 × 10(-12)), T2D risk (OR[95%CI]=0.86[0.76-0.96], P=0.010), early insulin secretion (β=-0.07±0.035 pmolinsulin mmolglucose(-1), P=0.048), but higher 2-h glucose (β=0.16±0.05 mmol l(-1), P=4.3 × 10(-4)). We identify a gene-based association with FG at G6PC2 (pSKAT=6.8 × 10(-6)) driven by four rare protein-coding SNVs (H177Y, Y207S, R283X and S324P). We identify rs651007 (MAF=20%) in the first intron of ABO at the putative promoter of an antisense lncRNA, associating with higher FG (β=0.02±0.004 mmol l(-1), P=1.3 × 10(-8)). Our approach identifies novel coding variant associations and extends the allelic spectrum of variation underlying diabetes-related quantitative traits and T2D susceptibility.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.234
Threshold uncertainty score0.357
Codex and Gemma teacher scores by category
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Teacher spread0.244 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
