Venous Thromboembolism Prophylaxis and Treatment in Patients With Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update 2014
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- Teacher spread
- 0.378 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
PURPOSE: To provide current recommendations about the prophylaxis and treatment of venous thromboembolism (VTE) in patients with cancer. METHODS: PubMed and the Cochrane Library were searched for randomized controlled trials, systematic reviews, meta-analyses, and clinical practice guidelines from November 2012 through July 2014. An update committee reviewed the identified abstracts. RESULTS: Of the 53 publications identified and reviewed, none prompted a change in the 2013 recommendations. RECOMMENDATIONS: Most hospitalized patients with active cancer require thromboprophylaxis throughout hospitalization. Routine thromboprophylaxis is not recommended for patients with cancer in the outpatient setting. It may be considered for selected high-risk patients. Patients with multiple myeloma receiving antiangiogenesis agents with chemotherapy and/or dexamethasone should receive prophylaxis with either low-molecular weight heparin (LMWH) or low-dose aspirin. Patients undergoing major surgery should receive prophylaxis starting before surgery and continuing for at least 7 to 10 days. Extending prophylaxis up to 4 weeks should be considered in those undergoing major abdominal or pelvic surgery with high-risk features. LMWH is recommended for the initial 5 to 10 days of treatment for deep vein thrombosis and pulmonary embolism as well as for long-term secondary prophylaxis (at least 6 months). Use of novel oral anticoagulants is not currently recommended for patients with malignancy and VTE because of limited data in patients with cancer. Anticoagulation should not be used to extend survival of patients with cancer in the absence of other indications. Patients with cancer should be periodically assessed for VTE risk. Oncology professionals should educate patients about the signs and symptoms of VTE.
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The record
- Venue
- Journal of Clinical Oncology
- Topic
- Venous Thromboembolism Diagnosis and Management
- Field
- Medicine
- Canadian institutions
- University of British Columbia Hospital
- Funders
- National Heart, Lung, and Blood InstituteUniversity of North Carolina at Chapel HillWilmot Cancer Institute, University of Rochester Medical CenterUniversidad de GranadaMcMaster UniversitySchool of Medicine, Emory UniversityPennsylvania State UniversityUniversity of PennsylvaniaPenn State Hershey Cancer InstituteUniversity of RochesterEmory UniversityCleveland ClinicUniversity of WashingtonUniversity of Southern California
- Keywords
- MedicineGuidelineCancerPulmonary embolismDeep veinIntensive care medicineRandomized controlled trialClinical trialLow molecular weight heparinThrombosisMalignancyInternal medicineSurgery
- Has abstract in OpenAlex
- yes