Genetic analysis for a shared biological basis between migraine and coronary artery disease
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.
Full frame distilled prediction
Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
- Candidate categories
- none
- Consensus categories
- none
- Domain
- Candidate signal: noneConsensus signal: none
- Study design
- Candidate signal: ObservationalConsensus signal: Observational
- Genre
- Candidate signal: EmpiricalConsensus signal: Empirical
- Teacher disagreement score
- 0.012
- Threshold uncertainty score
- 0.579
- Validation status
machine_predicted_unvalidated·codex-gemma-dda1882f352a
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
- Teacher spread
- 0.217 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
OBJECTIVE: To apply genetic analysis of genome-wide association data to study the extent and nature of a shared biological basis between migraine and coronary artery disease (CAD). METHODS: Four separate methods for cross-phenotype genetic analysis were applied on data from 2 large-scale genome-wide association studies of migraine (19,981 cases, 56,667 controls) and CAD (21,076 cases, 63,014 controls). The first 2 methods quantified the extent of overlapping risk variants and assessed the load of CAD risk loci in migraineurs. Genomic regions of shared risk were then identified by analysis of covariance patterns between the 2 phenotypes and by querying known genome-wide significant loci. RESULTS: We found a significant overlap of genetic risk loci for migraine and CAD. When stratified by migraine subtype, this was limited to migraine without aura, and the overlap was protective in that patients with migraine had a lower load of CAD risk alleles than controls. Genes indicated by 16 shared risk loci point to mechanisms with potential roles in migraine pathogenesis and CAD, including endothelial dysfunction (PHACTR1) and insulin homeostasis (GIP). CONCLUSIONS: The results suggest that shared biological processes contribute to risk of migraine and CAD, but surprisingly this commonality is restricted to migraine without aura and the impact is in opposite directions. Understanding the mechanisms underlying these processes and their opposite relationship to migraine and CAD may improve our understanding of both disorders.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- Neurology Genetics
- Topic
- Migraine and Headache Studies
- Field
- Medicine
- Canadian institutions
- not available
- Funders
- Institute of GeneticsNational Institute of Neurological Disorders and StrokeNational Cancer InstituteNational Institute of Mental HealthNational Heart, Lung, and Blood InstituteNational Institute on Alcohol Abuse and AlcoholismUniversitätsmedizin der Johannes Gutenberg-Universität MainzUniversitätsklinikum Hamburg-EppendorfNational Institutes of HealthKing's College LondonAcademy of FinlandTerveyden ja hyvinvoinnin laitosHelsingin ja Uudenmaan SairaanhoitopiiriTurun Yliopistollinen KeskussairaalaCentre for Medical Systems BiologyUniversité de BordeauxSuomen KulttuurirahastoOulun YliopistoTurun YliopistoUniversity of PennsylvaniaMedizinische Universität GrazEmil Aaltosen SäätiöDeutsche ForschungsgemeinschaftNederlandse Organisatie voor Wetenschappelijk OnderzoekTechnische Universität MünchenTampereen YliopistoJuho Vainion SäätiöAvera Institute for Human GeneticsHáskóli ÍslandsBundesministerium für Bildung und ForschungSamfundet FolkhälsanUniversität zu LübeckQueensland University of TechnologyEberhard Karls Universität TübingenUniversiteit LeidenSchool of Medicine, Stanford UniversityInstitut National de la Santé et de la Recherche MédicaleKarl-Franzens-Universität GrazUniversity of BristolUniversität HeidelbergVrije Universiteit AmsterdamUniversity of OttawaDeutsches Zentrum für Herz-KreislaufforschungFP7 HealthImperial College LondonBiocenter, University of OuluNational Institute for Health and Care ResearchFolkhälsanin TutkimussäätiöEuropean CommissionNorges Teknisk-Naturvitenskapelige UniversitetTampereen TuberkuloosisäätiöKelaUniversity of LeedsMedical Research CouncilInstitute for Translational Medicine and TherapeuticsWellcome TrustPaavo Nurmen SäätiöZonMwAmgen
- Keywords
- MigraineAuraGenome-wide association studyMigraine with auraCoronary artery diseaseGenetic associationGeneticsDiseaseBioinformaticsBiologyMedicineInternal medicineSingle-nucleotide polymorphismGeneGenotype
- Has abstract in OpenAlex
- yes