Large Deformation Characterization of Porcine Thoracic Aortas: Inverse Modeling Fitting of Uniaxial and Biaxial Tests
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Abstract
The elastic behavior of arteries is nonlinear when subjected to large deformations. In order to measure their anisotropic behavior, planar biaxial tests are often used. Typically, hooks are attached along the borders of a square sample of arterial tissue. Cruciform samples clamped with grips can also be used. The current debate on the effect of different biaxial test boundary conditions revolves around the uniformity of the stress distribution in the center of the specimen. Uniaxial tests are also commonly used due to simplicity of data analysis, but their capability to fully describe the in vivo behavior of a tissue remains to be proven. In this study, we demonstrate the use of inverse modeling to fit the material properties by taking into account the non-uniform stress distribution, and discuss the differences between the three types of tests. Square and cruciform samples were dissected from pig aortas and tested equi-biaxially. Rectangular samples were used in uniaxial testing as well. On the square samples, forces were applied on each side of edge sample attached with hooks, and strains were measured in the center using optical tracking of ink dots. On the cruciform and rectangular samples, displacements were applied on grip clamps and forces were measured on the clamps. Each type of experiment was simulated with the finite element method. The parameters of the Mooney-Rivlin constitutive model were adjusted with an optimization algorithm so that the simulation predictions fitted the experimental results. Higher stretch ratios (>1.5) were reached in the cruciform and rectangular samples than in the square samples before failure. Therefore, the nonlinear behavior of the tissue in large deformations was better captured by the cruciform biaxial test and the uniaxial test, than by the square biaxial test. Advantages of cruciform samples over square samples include: 1) higher deformation range; 2) simpler data acquisition and 3) easier attachment of sample. However, the nonuniform stress distribution in cruciform samples requires the use of inverse modeling adjustment of constitutive model parameters.
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Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
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Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
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