Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
Machine scores (provisional)
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
- Teacher spread
- 0.281 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
Transcranical direct current stimulation (tDCS) is a treatment known to ameliorate various neurological conditions and enhance memory and cognition in humans. tDCS has gained traction for its potential therapeutic value; however, little is known about its mechanism of action. Using a transgenic mouse expressing G-CaMP7 in astrocytes and a subpopulation of excitatory neurons, we find that tDCS induces large-amplitude astrocytic Ca(2+) surges across the entire cortex with no obvious changes in the local field potential. Moreover, sensory evoked cortical responses are enhanced after tDCS. These enhancements are dependent on the alpha-1 adrenergic receptor and are not observed in IP3R2 (inositol trisphosphate receptor type 2) knockout mice, in which astrocytic Ca(2+) surges are absent. Together, we propose that tDCS changes the metaplasticity of the cortex through astrocytic Ca(2+)/IP3 signalling.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- Nature Communications
- Topic
- Transcranial Magnetic Stimulation Studies
- Field
- Neuroscience
- Canadian institutions
- —
- Funders
- RIKEN Brain Science InstituteNational Institute for Basic BiologyUniversity of PennsylvaniaYork UniversityCouncil for Science and Technology PolicyJapan Society for the Promotion of ScienceLeibniz-GemeinschaftMinistry of Education, Culture, Sports, Science and TechnologyRIKENJapan Agency for Medical Research and Development
- Keywords
- NeuroscienceTranscranial direct-current stimulationStimulationExcitatory postsynaptic potentialNeuroplasticityKnockout mouseGenetically modified mouseBiologyTransgeneChemistryReceptorMedicineInternal medicineInhibitory postsynaptic potentialGene
- Has abstract in OpenAlex
- yes