Automated Translational and Rotational Control of Biological Cells With a Robot-Aided Optical Tweezers Manipulation System
Why this work is in the frame
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Bibliographic record
Abstract
Research and biomedical applications in cell surgery require transportation and rotation of biological cells. In these cell manipulation tasks, the cell of interest must be translated and oriented properly such that the desired component, such as the polar body or other organelles, can be imaged with optical microscopy. This paper presents a holographic optical tweezers (HOT) based system to carry out automated translational control in the plane, and rotational control about one rotational axes of a suspended cell. Based on the proposed general equations of motion of the cell, held in an optical trap, two controllers, one for cell translational and one for rotational control, are developed to translate and orient the cells to the desired position and orientation in a sequential manner. Experiments are performed to demonstrate the effectiveness of the proposed approach.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it