Exploring Familial Relationships Using Multiple Sequence Alignment
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Over the course of the past 30 yr, a multitude of calcium-binding proteins has been discovered that employ several unique structural motifs for calciumion binding. The first prominent family identified bound calcium via a helixloop-helix structural motif, and was coined the EF-hand binding motif, as it occurs between the E and F helices of carp parvalbumin (1). Today, the EF-hand calcium-binding family is ubiquitous, with members implicated in varied roles such as calcium signaling cell response and calcium storage. More recently, other calcium-binding motifs such as those found in annexin repeats (2), C2 domain proteins (3), and EGF domain proteins (4) have been identified. Table 1 summarizes the characteristic amino acid sequence properties of each of these domains as provided in the PROSITE protein motif recognition database (5).
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it