Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Mitochondrial DNA (mtDNA) nucleoids have been isolated from several organisms, including rat (liver) (), Physarum polycephalum (), Saccharomy- ces cerevisiae () and Pichia jadinii (). Most methods for nucleoid isolation have utilized detergent extraction and sucrose gradient centrifugation to separate bulk mitochondrial protein from mtDNA-associated proteins (e.g., ref. 5). The disadvantages of these methods include contamination by non-nucleoid proteins and the possibility of losing those nucleoid proteins that are not tightly bound to the complex under the conditions of the fractionation. To circumvent these problems, we have developed an in organello formaldehyde crosslinking method for isolating mtDNA nucleoids that stabilizes protein content and reduces the potential for contamination by irrelevant mitochondrial (and cellular) proteins. Additionally, it has long been suggested that mtDNA is associated with the inner membrane. To begin exploring that notion, we have used ultraviolet (UV) crosslinking as a means of detecting the binding of proteins from membrane-enriched fractions to specific sequences of mtDNA.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it