Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
Abstract
Oligodendrocytes have been considered as a functionally homogeneous population in the central nervous system (CNS). We performed single-cell RNA sequencing on 5072 cells of the oligodendrocyte lineage from 10 regions of the mouse juvenile and adult CNS. Thirteen distinct populations were identified, 12 of which represent a continuum from Pdgfra(+) oligodendrocyte precursor cells (OPCs) to distinct mature oligodendrocytes. Initial stages of differentiation were similar across the juvenile CNS, whereas subsets of mature oligodendrocytes were enriched in specific regions in the adult brain. Newly formed oligodendrocytes were detected in the adult CNS and were responsive to complex motor learning. A second Pdgfra(+) population, distinct from OPCs, was found along vessels. Our study reveals the dynamics of oligodendrocyte differentiation and maturation, uncoupling them at a transcriptional level and highlighting oligodendrocyte heterogeneity in the CNS.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- Science
- Topic
- Neurogenesis and neuroplasticity mechanisms
- Field
- Neuroscience
- Canadian institutions
- —
- Funders
- Biotechnology and Biological Sciences Research CouncilNatural Sciences and Engineering Research Council of CanadaSeventh Framework ProgrammeNovo Nordisk FondenNational Natural Science Foundation of ChinaH2020 European Research CouncilCancerfondenStiftelsen för Strategisk ForskningKarolinska InstitutetEuropean CommissionNovo Nordisk UK Research FoundationWellcome TrustNational Science FoundationWellcomeDivision of Graduate EducationVetenskapsrådetHuman Frontier Science Program
- Keywords
- JuvenileCentral nervous systemOligodendrocyteBiologyNeuroscienceMyelinGenetics
- Has abstract in OpenAlex
- yes