Circulating plant miRNAs can regulate human gene expression in vitro
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Post-publication record
- Nature
- Retraction
- Reason
- Error in Data;
- Date
- 5/22/2017 0:00
- Flagged by OpenAlex?
- Yes
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Abstract
While Brassica oleracea vegetables have been linked to cancer prevention, the exact mechanism remains unknown. Regulation of gene expression by cross-species microRNAs has been previously reported; however, its link to cancer suppression remains unexplored. In this study we address both issues. We confirm plant microRNAs in human blood in a large nutrigenomics study cohort and in a randomized dose-controlled trial, finding a significant positive correlation between the daily amount of broccoli consumed and the amount of microRNA in the blood. We also demonstrate that Brassica microRNAs regulate expression of human genes and proteins in vitro, and that microRNAs cooperate with other Brassica-specific compounds in a possible cancer-preventive mechanism. Combined, we provide strong evidence and a possible multimodal mechanism for broccoli in cancer prevention.
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The record
- Venue
- Scientific Reports
- Topic
- MicroRNA in disease regulation
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- Public Health OntarioWomen's College HospitalLunenfeld-Tanenbaum Research InstituteUniversity Health NetworkUniversity of TorontoPrincess Margaret Cancer CentreDiscovery Centre
- Funders
- —
- Keywords
- microRNAGene expressionGeneIn vitroBiologyRegulation of gene expressionCell biologyComputational biologyBioinformaticsGenetics
- Has abstract in OpenAlex
- yes