A Randomised, Placebo-Controlled, Crossover Study Investigating the Effects of Nicotine Gum on Strength, Power and Anaerobic Performance in Nicotine-Naïve, Active Males
Bibliographic record
Abstract
Nicotine use amongst athletes is high and increasing, especially team sports, yet the limited previous studies investigating the performance consequences of this behaviour have not examined the effects of the principal active ingredient, nicotine, per se. Therefore, we determined whether nicotine gum affected muscular and anaerobic performance. Nine active males (24 ± 3 years) completed three trials in a random order in which 20 min prior to testing they chewed 2 mg (NIC-2), 4 mg (NIC-4) nicotine or flavour-matched placebo (PLA) gum. Peak and average peak isometric, concentric and eccentric leg extensor torque was measured followed by vertical counter-movement jump height and a 30-s Wingate test. Heart rate was measured whilst capillary blood samples determined pH, HCO3 − and venous blood confirmed the presence of nicotine. Nicotine was confirmed by the presence of its major metabolite, cotinine and participants reported no side effects with nicotine. Peak and average peak isometric and eccentric torque was significantly affected (NIC-2 > PLA; p < 0.05) whilst peak (NIC-2 > PLA; p < 0.05) but not average peak (p > 0.05) concentric torque was different between trials. Counter-movement jump height was similar across trials (p > 0.05). Anaerobic capacity during the Wingate remained similar across trials (p > 0.05); however, pacing strategy (peak power and rate of fatigue) was different during NIC-2 than PLA. pH was affected by nicotine (NIC-2 > PLA; p < 0.05) and was reduced following the Wingate in all trials. HCO3 − showed similar responses across trials (p > 0.05) although it was also reduced following the Wingate (p < 0.05), whilst heart rate was significantly affected (NIC-2/NIC-4 > PLA; p < 0.05). Chewing low-dose (2 mg) nicotine gum 20 min prior to exercise significantly improved leg extensor torque but did not affect counter-movement jump height or Wingate performance compared to a placebo, whilst there were minimal effects of the 4 mg nicotine gum on the performance parameters measured.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.003 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.006 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".