SU56. Impaired Illness Awareness and Leftward Visuospatial Inattention in Schizophrenia Are Attributable to a Common Neural Deficit—Posterior Parietal Hemispheric Imbalance
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Bibliographic record
Abstract
Background: Visuospatial attention in healthy adults is primarily controlled by the right posterior parietal cortex, resulting in a slight leftward bias in visuospatial attention referred to as “pseudoneglect.” By comparison, individuals with schizophrenia exhibit an abnormal rightward visuospatial bias similar to patients with hemineglect due to right posterior parietal lesions. In addition to visuospatial inattention, posterior parietal dysfunction is implicated in impaired illness awareness in both individuals with structural brain damage (eg, stroke) and those with schizophrenia. Methods: The aim of the present study was to investigate whether abnormalities in visuospatial attention are related to impaired illness awareness in schizophrenia, suggestive of a shared neural deficit. The baseline data from a pilot study consisting of 8 participants with schizophrenia or schizoaffective disorder with moderate to severe impairment in illness awareness were analyzed. Correlation analyses were performed between scores on a line bisection test (LBT) and illness awareness assessed using the VAGUS scale – Self-report version (VAGUS-SR). The VAGUS-SR measures different aspects of illness awareness, including General Illness Awareness, Symptom Attribution, Awareness of Need for Treatment, and Awareness of Negative Consequences, which are averaged to generate a total score. Results: The VAGUS-SR Symptom Attribution subscale scores were reliably negatively correlated with LBT scores across study visits. The VAGUS-SR average total score and General Illness Awareness subscale scores were related to LBT scores in the same direction; however, these associations did not reach statistical significance. Subsequent partial correlation analyses controlling for illness severity revealed the same results. Conclusion: Our pilot study suggests that abnormal visuospatial bias and impaired illness awareness in schizophrenia are related and may in part be manifestations of a common neural deficit, ie, posterior parietal dysfunction. Future investigations with larger sample sizes are required to substantiate this hypothesis.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it