Diabetic retinopathy: current understanding, mechanisms, and treatment strategies
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
Abstract
Diabetic retinopathy (DR) causes significant visual loss on a global scale. Treatments for the vision-threatening complications of diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) have greatly improved over the past decade. However, additional therapeutic options are needed that take into account pathology associated with vascular, glial, and neuronal components of the diabetic retina. Recent work indicates that diabetes markedly impacts the retinal neurovascular unit and its interdependent vascular, neuronal, glial, and immune cells. This knowledge is leading to identification of new targets and therapeutic strategies for preventing or reversing retinal neuronal dysfunction, vascular leakage, ischemia, and pathologic angiogenesis. These advances, together with approaches embracing the potential of preventative or regenerative medicine, could provide the means to better manage DR, including treatment at earlier stages and more precise tailoring of treatments based on individual patient variations.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- JCI Insight
- Topic
- Retinal Diseases and Treatments
- Field
- Medicine
- Canadian institutions
- —
- Funders
- National Eye InstituteNational Institutes of HealthScience Foundation IrelandQueen's UniversityJohns Hopkins UniversityQueen's University BelfastMedical Research CouncilRoyal SocietyMassachusetts Lions Eye Research Fund
- Keywords
- Diabetic retinopathyMedicineNeurovascular bundleDiabetes mellitusRetinaRetinalNeuroscienceIschemiaOphthalmologyIntensive care medicinePathologyInternal medicinePsychologyEndocrinology
- Has abstract in OpenAlex
- yes