Decreased Neural Response to Threat Differentiates Patients Who Have Attempted Suicide From Nonattempters With Current Ideation
Bibliographic record
Abstract
Suicide prevention efforts have not slowed suicide rates, in part because of limited understanding of differences in risk for suicide ideation versus suicide attempts. Reduced fear of pain and death may be key to this distinction. In the present study we examine whether blunted neural response to threat of death, bodily harm, or illness, measured by the late positive potential (LPP), differentiates individuals who had previously attempted suicide from individuals who had never attempted suicide, controlling for current levels of suicidal ideation. We compared psychiatric outpatients with no history of suicide attempts ( n = 152) and those with a history of suicide attempts ( n = 83). Attempters exhibited a blunted threat-elicited LPP compared to patients with no history of attempts, regardless of current ideation. Findings suggest diminished neural response to threat can distinguish attempters from ideators and might be a target for future research on the transition from ideation to action.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".