Decreased Neural Response to Threat Differentiates Patients Who Have Attempted Suicide From Nonattempters With Current Ideation
Why this work is in the frame
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Bibliographic record
Abstract
Suicide prevention efforts have not slowed suicide rates, in part because of limited understanding of differences in risk for suicide ideation versus suicide attempts. Reduced fear of pain and death may be key to this distinction. In the present study we examine whether blunted neural response to threat of death, bodily harm, or illness, measured by the late positive potential (LPP), differentiates individuals who had previously attempted suicide from individuals who had never attempted suicide, controlling for current levels of suicidal ideation. We compared psychiatric outpatients with no history of suicide attempts ( n = 152) and those with a history of suicide attempts ( n = 83). Attempters exhibited a blunted threat-elicited LPP compared to patients with no history of attempts, regardless of current ideation. Findings suggest diminished neural response to threat can distinguish attempters from ideators and might be a target for future research on the transition from ideation to action.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.002 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it