Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950–Metabolites in Frozen Human Plasma
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Full frame distilled prediction
Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
- Candidate categories
- none
- Consensus categories
- none
- Domain
- Candidate signal: noneConsensus signal: none
- Study design
- Candidate signal: Bench or experimentalConsensus signal: Bench or experimental
- Genre
- Candidate signal: EmpiricalConsensus signal: Empirical
- Teacher disagreement score
- 0.166
- Threshold uncertainty score
- 0.874
- Validation status
machine_predicted_unvalidated·codex-gemma-dda1882f352a
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
- Teacher spread
- 0.244 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
As the lipidomics field continues to advance, self-evaluation within the community is critical. Here, we performed an interlaboratory comparison exercise for lipidomics using Standard Reference Material (SRM) 1950-Metabolites in Frozen Human Plasma, a commercially available reference material. The interlaboratory study comprised 31 diverse laboratories, with each laboratory using a different lipidomics workflow. A total of 1,527 unique lipids were measured across all laboratories and consensus location estimates and associated uncertainties were determined for 339 of these lipids measured at the sum composition level by five or more participating laboratories. These evaluated lipids detected in SRM 1950 serve as community-wide benchmarks for intra- and interlaboratory quality control and method validation. These analyses were performed using nonstandardized laboratory-independent workflows. The consensus locations were also compared with a previous examination of SRM 1950 by the LIPID MAPS consortium. While the central theme of the interlaboratory study was to provide values to help harmonize lipids, lipid mediators, and precursor measurements across the community, it was also initiated to stimulate a discussion regarding areas in need of improvement.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- Journal of Lipid Research
- Topic
- Metabolomics and Mass Spectrometry Studies
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- Concordia UniversityUniversity of VictoriaMcGill UniversityHospital for Sick ChildrenGenome British ColumbiaJewish General Hospital
- Funders
- Advanced Low Carbon Technology Research and Development ProgramCore Research for Evolutional Science and TechnologyNational Center for Advancing Translational SciencesOffice of Experimental Program to Stimulate Competitive ResearchNational Center for Research ResourcesNational Institute of Diabetes and Digestive and Kidney DiseasesNational Heart, Lung, and Blood InstituteNatural Sciences and Engineering Research Council of CanadaCanadian Institutes of Health ResearchNational Institute of Standards and TechnologyNational Research Foundation SingaporeNational Institute for Health Research Southampton Biomedical Research CentreDirectorate for Biological SciencesNational Institutes of HealthNational Institute of General Medical SciencesWarren Y. Soper Charitable TrustNational Cancer InstituteGenome AlbertaJapan Science and Technology AgencyGeorgia Clinical and Translational Science AllianceVetenskapsrådetHjärt-LungfondenAustrian Science FundNational University of SingaporeNational Research FoundationLeading Edge Endowment FundMcGill UniversityJapan Agency for Medical Research and DevelopmentGenome British ColumbiaFondation De Famille Alvin SegalSteno Diabetes Center CopenhagenKansas IDeA Network of Biomedical Research ExcellenceJewish General HospitalNational Institute for Health and Care ResearchGenome CanadaNational Science Foundation
- Keywords
- LipidomicsNISTWorkflowChemistryComputer scienceBiochemistryDatabase
- Has abstract in OpenAlex
- yes