Sex Differences in the Cortisol Response to the Trier Social Stress Test in Depressed and Nondepressed Adolescents
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Two of the most robust findings in depression research are (a) that women are twice as likely to become depressed than men and (b) that stress is an important risk factor for depression. Although sex differences in stress reactivity may be an important determinant of differential risk for depression, few studies have examined sex differences in neurobiological reactivity to stress. The purpose of the current study was to assess sex differences in the HPA axis response to stress in depressed versus healthy controls by comparing the cortisol response to the Trier Social Stress Test in a community sample of adolescents (ages 12–18). Depressed boys showed significantly heightened cortisol reactivity compared with depressed girls, whose response was blunted compared with nondepressed girls. This diverging pattern of cortisol reactivity to stress among depressed girls and boys may help to explain the sex difference in depression prevalence that emerges during the adolescent period.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.030 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.001 | 0.004 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.004 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it