Optimizations for neuron time warp(NTW) for stochastic reaction-diffusion models of neurons
Bibliographic record
Abstract
The intracellular calcium signaling pathways of a neuron consist of biochemical reactions along with molecular diffusion. It is known that stochastic discrete event simulation of these pathways provides a more detailed understanding of the pathways than deterministic simulators because they capture behavior at a molecular level. Our research employs a parallel discrete event simulation simulator, Neuron Time Warp (NTW), which is intended for use for the simulation of neurons. In previous work we built a discrete event Ca2+ wave model. However, we did not achieve the expected performance because of an imbalance in the computation between the area of the neuron covered by the Ca2+ wave and the remaining area of the neuron. In this paper we describe a dynamic load balancing algorithm and a dynamic window control algorithm for NTW. We make use of Q-learning to determine the basic parameters of the algorithm. Using this algorithm we obtained an improvement in the performance of the simulator of up to 30%.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.005 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".