Association of plasma nitrite levels with obesity and metabolic syndrome in the Old Order Amish
Why this work is in the frame
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Bibliographic record
Abstract
Summary Objectives Plasma nitrite is a metabolite of nitric oxide and reflects endogenous nitric oxide synthase (NOS) activity. Although plasma nitrites were previously linked with obesity and metabolic syndrome (MetS), the direction of association remains inconsistent, possibly due to sample heterogeneity. In a relatively homogeneous population, we hypothesized that nitrite levels will be positively associated with overweight/obesity and MetS. Methods Fasting nitrite levels were measured in 116 Old Order Amish (78% women). We performed age‐and‐sex‐adjusted ancova s to compare nitrite levels between three groups (a) overweight/obese(−)MetS(−), (b) overweight/obese(+)MetS(−) and (c) overweight/obese(+)MetS)(+). Multivariate linear regressions were conducted on nitrite associations with continuous metabolic variables, with successive adjustments for demographics, body mass index, C‐reactive protein and neopterin. Results Nitrite levels were higher in the obese/overweight(+)MetS(+) group than in the other two groups ( p < 0.001). Nitrites were positively associated with levels of triglycerides ( p < 0.0001), total cholesterol ( p = 0.048), high‐density lipoprotein/cholesterol ratio ( p < 0.0001) and fasting glucose ( p < 0.0001), and negatively correlated with high‐density lipoprotein‐cholesterol ( p < 0.0001). These associations were robust to adjustments for body mass index and inflammatory markers. Conclusion Further investigation of the connection between obesity/MetS and plasma nitrite levels may lead to novel dietary and pharmacological approaches that ultimately may contribute to reducing the increasing burden of obesity, MetS and cardiovascular morbidity and mortality.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.005 | 0.006 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it