Behavioral Comorbidities in Dextran Sulphate Sodium (DSS) Colitis, an animal model of Inflammatory Bowel Diseases
Why this work is in the frame
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Bibliographic record
Abstract
Inflammatory Bowel Diseases (IBD), which include Crohn's disease and ulcerative colitis represent a group of incurable lifelong diseases affecting about 0.67% of the Canadian population (2012) and severely impacts the health‐related quality of life through ongoing debilitating symptoms like pain, gastrointestinal dysfunction as well as behavioral comorbidities like anxiety, depression, fatigue and cognitive impairment. Depression and anxiety are prevalent in individuals with IBD at a rate that outpaces the general population thereby substantially increasing the burden of the disease, as well as economic cost of managing it. Although clinical surveys and population studies have established a strong relation between IBD, depression and anxiety disorders, our knowledge of CNS changes is limited. We therefore investigated these comorbidities in a mice model of IBD with similarities to Ulcerative colitis, caused by administration of Dextran sulphate sodium (DSS) in drinking water for 5 days. In male and female mice, DSS treatment caused increased increased brain excitability, revealed by a decrease in seizure onset times after intraperitoneal administration of 25mg/kg body weight of Kainic acid; this was positively correlated with the intensity of inflammation only in males. Moreover, both sexes showed an increased anxiety‐related behavior on the elevated plus‐maze (EPM). We assessed pain levels, because they may influence behavioral response; only male mice were hyperalgesic when tested on the hotplate for thermal pain sensitivity indicating that altered behavioral responses cannot be entirely attributed to an interference with a movement brought about by pain. Further studies mapping the CNS pathways integral to the above changes will reveal novel mechanisms as to how peripheral inflammation results in changes in central immune‐mediated affective behaviors. Support or Funding Information This work is supported by Alberta Innovates‐Health Solutions (AI‐HS) and Canadian Institutes of Health Research team grants, and by the Hotchkiss Brain Institute and AI‐HS personnel support awards.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it