Flexible piecewise linear model for investigating dose‐response relationship in meta‐analysis: Methodology, examples, and comparison
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
OBJECTIVES: Dose-response meta-analysis (DRMA) is widely employed in establishing the potential dose-response relationship between continuous exposures and disease outcomes. However, there is no valid DRMA method readily for discrete exposures, especially when the possible dose-response trend not likely to be linear. We proposed a piecewise linear DRMA model as a solution to this issue. METHODS: We illustrated the methodology of piecewise linear model in both one-stage DRMA approach and two-stage DRMA approach. The method by testing the equality of slopes of each piecewise was employed to judge if there is "piecewise effect" against a simple linear trend. We then used sleep (continuous exposure) and parity (discrete exposure) data as examples to illustrate how to apply the model in DRMA using the Stata code attached. We also empirically compared the slopes of piecewise linear model with simple linear as well as restricted cubic spline model. RESULTS: Both one-stage and two-stage piecewise linear DRMA model fitted well in our examples, and the results were similar. Obvious "piecewise effects" were detected in both the two samples by the method we used. In our example, the new model showed a better fitting effect and practical, reliable results compared to the simple linear model, while similar results for to restricted cubic spline model. CONCLUSION: Piecewise linear function is a valid and straightforward method for DRMA and can be used for discrete exposures, especially when the simple linear function is under fitted. It represents a superior model to linear model in DRMA and may be an alternative model to the nonlinear model.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Direct model labels (unvalidated)
Per-model category and study-design labels from the labeling rounds. They are machine output, unvalidated, and the disagreement between models ships as data. No study design here is MEDLINE-validated yet.
| Model arm | Categories | Study design | Confidence |
|---|---|---|---|
| gemma | no category Domain: not available · Genre: Methods About the Canadian research system: no · About a Canadian topic: no | Simulation or modeling | high |
| gpt | no category Domain: not available · Genre: Methods About the Canadian research system: no · About a Canadian topic: no | Simulation or modeling | medium |
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.011 | 0.015 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it