Oligodendrocyte Progenitor Cells Become Regionally Diverse and Heterogeneous with Age
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
Machine scores (provisional)
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
- Teacher spread
- 0.196 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
Oligodendrocyte progenitor cells (OPCs), which differentiate into myelinating oligodendrocytes during CNS development, are the main proliferative cells in the adult brain. OPCs are conventionally considered a homogeneous population, particularly with respect to their electrophysiological properties, but this has been debated. We show, by using single-cell electrophysiological recordings, that OPCs start out as a homogeneous population but become functionally heterogeneous, varying both within and between brain regions and with age. These electrophysiological changes in OPCs correlate with the differentiation potential of OPCs; thus, they may underlie the differentiational differences in OPCs between regions and, likewise, differentiation failure with age.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- Neuron
- Topic
- Neurogenesis and neuroplasticity mechanisms
- Field
- Neuroscience
- Canadian institutions
- —
- Funders
- Wellcome - MRC Cambridge Stem Cell Institute, University of CambridgeBiotechnology and Biological Sciences Research CouncilEuropean Research CouncilFonds de Recherche du Québec - SantéGates Cambridge TrustMedical Research CouncilDirectorate for Biological SciencesWellcome TrustCambridge TrustEuropean CommissionLister Institute of Preventive MedicineMultiple Sclerosis SocietyPaul G. Allen Frontiers GroupPaul G. Allen Family Foundation
- Keywords
- NeuroscienceHomogeneousProgenitor cellBiologyElectrophysiologyOligodendrocytePopulationProgenitorStem cellMyelinCentral nervous systemCell biologyMedicine
- Has abstract in OpenAlex
- yes