CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
Abstract
Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections and cancers in animal models and humans. Tex cells are characterized by progressive loss of effector functions, high and sustained inhibitory receptor expression, metabolic dysregulation, poor memory recall and homeostatic self-renewal, and distinct transcriptional and epigenetic programs. The ability to reinvigorate Tex cells through inhibitory receptor blockade, such as αPD-1, highlights the therapeutic potential of targeting this population. Emerging insights into the mechanisms of exhaustion are informing immunotherapies for cancer and chronic infections. However, like other immune cells, Tex cells are heterogeneous and include progenitor and terminal subsets with unique characteristics and responses to checkpoint blockade. Here, we review our current understanding of Tex cell biology, including the developmental paths, transcriptional and epigenetic features, and cell intrinsic and extrinsic factors contributing to exhaustion and how this knowledge may inform therapeutic targeting of Tex cells in chronic infections, autoimmunity, and cancer.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- Annual Review of Immunology
- Topic
- Immune Cell Function and Interaction
- Field
- Immunology and Microbiology
- Canadian institutions
- —
- Funders
- Fonds de Recherche du Québec - SantéCanadian Institutes of Health ResearchParker Institute for Cancer ImmunotherapyCancer Research InstitutePublic Health AgencyNational Institutes of HealthPublic Health Agency of CanadaUniversity of Pennsylvania
- Keywords
- BiologyImmunologyEpigeneticsImmune checkpointImmune systemAutoimmunityCD8PopulationCancerCytotoxic T cellEffectorT cellChronic infectionBlockadeCancer researchImmunotherapyReceptorGeneticsMedicine
- Has abstract in OpenAlex
- yes