"RETRACTED ARTICLE: Vibrio parahaemolyticus RhsP represents a widespread group of pro-effectors for type VI secretion systems
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Post-publication record
- Nature
- Retraction
- Reason
- Manipulation of Images;
- Date
- 3/15/2019 0:00
- Flagged by OpenAlex?
- Yes
Source: Retraction Watch, joined by DOI. OpenAlex records retraction as is_retracted, a boolean over a state space with at least four values, so it cannot express an expression of concern, a correction or a reinstatement — it reports them as false, which reads as “fine”.
Abstract
Type VI secretion systems (T6SSs) translocate effector proteins, such as Rhs toxins, to eukaryotic cells or prokaryotic competitors. All T6SS Rhs-type effectors characterized thus far contain a PAAR motif or a similar structure. Here, we describe a T6SS-dependent delivery mechanism for a subset of Rhs proteins that lack a PAAR motif. We show that the N-terminal Rhs domain of protein RhsP (or VP1517) from Vibrio parahaemolyticus inhibits the activity of the C-terminal DNase domain. Upon auto-proteolysis, the Rhs fragment remains inside the cells, and the C-terminal region interacts with PAAR2 and is secreted by T6SS2; therefore, RhsP acts as a pro-effector. Furthermore, we show that RhsP contributes to the control of certain "social cheaters" (opaR mutants). Genes encoding proteins with similar Rhs and PAAR-interacting domains, but diverse C-terminal regions, are widely distributed among Vibrio species.
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The record
- Venue
- Nature Communications
- Topic
- Vibrio bacteria research studies
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- University of Calgary
- Funders
- U.S. National Library of MedicineResearch Institute for Microbial Diseases, Osaka UniversityCanadian Institutes of Health ResearchNational Institutes of HealthFundo para o Desenvolvimento das Ciências e da TecnologiaUniversidade de MacauSaint Louis University
- Keywords
- EffectorType VI secretion systemSecretionVibrio parahaemolyticusBiologyGeneProteolysisCell biologyMutantType three secretion systemMicrobiologyVirulenceGeneticsBacteriaBiochemistry
- Has abstract in OpenAlex
- yes