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Record W3022810005 · doi:10.1016/s0093-7754(01)90138-1

Surveillance for hepatocellular carcinoma

2001· review· en· W3022810005 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueSeminars in Oncology · 2001
Typereview
Languageen
FieldMedicine
TopicHepatocellular Carcinoma Treatment and Prognosis
Canadian institutionsUniversity Health NetworkUniversity of Toronto
Fundersnot available
KeywordsMedicineHepatocellular carcinomaCirrhosisHepatitis BRandomized controlled trialInternal medicineIntensive care medicine

Abstract

fetched live from OpenAlex

Surveillance for hepatocellular carcinoma (HCC) in patients with recognized risk factors remains controversial. The populations for whom surveillance may be appropriate include all patients with established cirrhosis, and hepatitis B (HBV) carriers, even in the absence of cirrhosis. However, even these risk groups can be stratified into patients with higher or lower risk. The most appropriate surveillance test is periodic ultrasound examination, although the optimum screening interval has not been defined. Alphafetoprotein (AFP) is a poor surveillance test, lacking in sensitivity and specificity. There are no randomized controlled trials confirming that surveillance for HCC reduces disease-specific mortality. Modeling studies, however, have suggested that screening is cost-effective and reduces group mortality by a small amount. The criteria by which cancer surveillance programs in general can be judged have been described. Surveillance for HCC meets some of these criteria, but not all. In particular, more effective treatments have to be developed to improve the outcome of surveillance. Although there is no firm evidence to support the practice of surveillance for HCC, this has become common practice, forever preventing the definitive study from being performed. Nonetheless, surveillance is recommended in order to identify patients with small HCCs, who can be entered into trials of therapy of these tumors.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.986
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0040.001
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.129
GPT teacher head0.366
Teacher spread0.237 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it