Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
fundA Canadian funder is recorded on the work.
VenueJAMA Psychiatry · 2020
Typearticle
Languageen
FieldNeuroscience
TopicFunctional Brain Connectivity Studies
Canadian institutionsMcMaster UniversityMcGill UniversityUniversity of CalgaryMontreal Neurological Institute and HospitalUniversity of TorontoDalhousie UniversitySt. Joseph’s Healthcare HamiltonUniversity of British ColumbiaHospital for Sick ChildrenCentre for Addiction and Mental HealthHolland Bloorview Kids Rehabilitation Hospital
FundersCilagNational Institute of Biomedical Imaging and BioengineeringNational Institute on Drug AbuseNational Institute of Mental HealthRussian Academy of SciencesNational Health and Medical Research CouncilMenzies Centre for Australian Studies, King's College London, University of LondonMedical Research CouncilCollege of Medicine, Seoul National UniversityNuclear PhysicsIrving Medical Center, Columbia UniversityInstitute of Psychiatry, Psychology and Neuroscience, King’s College LondonCumming School of Medicine, University of CalgaryMathison Centre for Mental Health Research and EducationState University of New York Upstate Medical UniversityWake Forest School of MedicineUniversity of California, IrvineMedical School, University of MichiganUniversity of California, Los AngelesSchool of Medicine, New York UniversityGenentechDirectorate for Biological SciencesNational Institutes of HealthAmsterdam NeuroscienceInstituto de Investigación Marqués de ValdecillaUniversitat Politècnica de ValènciaH. Lundbeck A/SMinistry of Science and Higher Education of the Russian FederationServierInnovative Medicines InitiativeUniversidade do MinhoJulius-Maximilians-Universität WürzburgChiba UniversityTechnische Universität DresdenUniversidad Autónoma de MadridUniversità di PisaUniversity of Cape TownInstituto de Salud Carlos IIIUniversidad de CantabriaUniversity of New South WalesRadboud Universitair Medisch CentrumFundación Alicia KoplowitzUniversidade de São PauloU.S. Department of Veterans AffairsNational University of IrelandRegion HovedstadenUniversität ZürichDeutsches Zentrum für Neurodegenerative ErkrankungenWestfälische Wilhelms-Universität MünsterRheinische Friedrich-Wilhelms-Universität BonnUniversiteit van AmsterdamUniversitair Medisch Centrum GroningenSanofiNeuroscience Research AustraliaLeids Universitair Medisch CentrumCity, University of LondonUniversitätsklinikum HeidelbergUniversitetet i BergenUniversity of ReadingUniversiteit StellenboschKunming Medical UniversityUniversitetet i OsloGeorgia Institute of TechnologyLundbeckfondenNIHR Maudsley Biomedical Research CentreDalhousie UniversityAix-Marseille UniversitéUniversiteit LeidenCentre Hospitalier Universitaire VaudoisEuropean Regional Development FundSeoul National UniversityFundação BialNational Center for Advancing Translational SciencesBrandeis UniversityBundesministerium für Bildung und ForschungVrije Universiteit AmsterdamMonash UniversityDeakin UniversityJapan Society for the Promotion of ScienceCoordenação de Aperfeiçoamento de Pessoal de Nível SuperiorRijksuniversiteit GroningenUniversidade Federal do Rio Grande do SulTechnische Universität MünchenDeutsche ForschungsgemeinschaftTrinity College DublinSouth African Medical Research CouncilAstraZenecaNorges Teknisk-Naturvitenskapelige UniversitetUniversiteit UtrechtMurdoch Children's Research InstituteEuropean CommissionUniversitat de BarcelonaCentre National de la Recherche ScientifiqueImperial College LondonKing's College LondonKarolinska InstitutetAmsterdam University Medical CentersYork UniversityUniversity of East LondonUniversity of California, San FranciscoNational Institute of Mental Health and NeurosciencesVanderbilt University Medical CenterNational Institute on AgingUniversity of BathMcMaster UniversityUniversity of OxfordUniversity of TorontoUniversity of MelbourneYale UniversityUniversity of Texas Health Science Center at HoustonDepartment of Psychiatry, Faculty of Medicine, University of British ColumbiaNational Institute for Health and Care ResearchGeorgia State UniversityPratt FoundationEmory UniversityChildren’s Hospital of Wisconsin Research InstituteUniversiteit MaastrichtUniversity of PittsburghUniversidad de SevillaUniversity of PennsylvaniaPhilipps-Universität MarburgUniversity of GalwayFundació la Marató de TV3Syracuse UniversityJohns Hopkins UniversityUniversitat Autònoma de BarcelonaMcGill UniversityUniversität BaselSeoul National University HospitalUniversity of SussexRWTH Aachen UniversityCentro de Investigación Biomédica en Red de Salud MentalRadboud UniversiteitEli Lilly and CompanyState University of New YorkUniversity of MinnesotaPerelman School of Medicine, University of PennsylvaniaMcLean HospitalBiogenNational Center of Neurology and PsychiatryUniversity of Southern California
KeywordsPsychologyNeurosciencePsychiatryMedicine
Abstract
fetched live from OpenAlexIMPORTANCE: Large-scale neuroimaging studies have revealed group differences in cortical thickness across many psychiatric disorders. The underlying neurobiology behind these differences is not well understood. OBJECTIVE: To determine neurobiologic correlates of group differences in cortical thickness between cases and controls in 6 disorders: attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BD), major depressive disorder (MDD), obsessive-compulsive disorder (OCD), and schizophrenia. DESIGN, SETTING, AND PARTICIPANTS: Profiles of group differences in cortical thickness between cases and controls were generated using T1-weighted magnetic resonance images. Similarity between interregional profiles of cell-specific gene expression and those in the group differences in cortical thickness were investigated in each disorder. Next, principal component analysis was used to reveal a shared profile of group difference in thickness across the disorders. Analysis for gene coexpression, clustering, and enrichment for genes associated with these disorders were conducted. Data analysis was conducted between June and December 2019. The analysis included 145 cohorts across 6 psychiatric disorders drawn from the ENIGMA consortium. The numbers of cases and controls in each of the 6 disorders were as follows: ADHD: 1814 and 1602; ASD: 1748 and 1770; BD: 1547 and 3405; MDD: 2658 and 3572; OCD: 2266 and 2007; and schizophrenia: 2688 and 3244. MAIN OUTCOMES AND MEASURES: Interregional profiles of group difference in cortical thickness between cases and controls. RESULTS: A total of 12 721 cases and 15 600 controls, ranging from ages 2 to 89 years, were included in this study. Interregional profiles of group differences in cortical thickness for each of the 6 psychiatric disorders were associated with profiles of gene expression specific to pyramidal (CA1) cells, astrocytes (except for BD), and microglia (except for OCD); collectively, gene-expression profiles of the 3 cell types explain between 25% and 54% of variance in interregional profiles of group differences in cortical thickness. Principal component analysis revealed a shared profile of difference in cortical thickness across the 6 disorders (48% variance explained); interregional profile of this principal component 1 was associated with that of the pyramidal-cell gene expression (explaining 56% of interregional variation). Coexpression analyses of these genes revealed 2 clusters: (1) a prenatal cluster enriched with genes involved in neurodevelopmental (axon guidance) processes and (2) a postnatal cluster enriched with genes involved in synaptic activity and plasticity-related processes. These clusters were enriched with genes associated with all 6 psychiatric disorders. CONCLUSIONS AND RELEVANCE: In this study, shared neurobiologic processes were associated with differences in cortical thickness across multiple psychiatric disorders. These processes implicate a common role of prenatal development and postnatal functioning of the cerebral cortex in these disorders.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.004
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.138
Threshold uncertainty score0.629
Codex and Gemma teacher scores by category
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Teacher spread0.228 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
