Printability and Shape Fidelity of Bioinks in 3D Bioprinting
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Abstract
Three-dimensional bioprinting uses additive manufacturing techniques for the automated fabrication of hierarchically organized living constructs. The building blocks are often hydrogel-based bioinks, which need to be printed into structures with high shape fidelity to the intended computer-aided design. For optimal cell performance, relatively soft and printable inks are preferred, although these undergo significant deformation during the printing process, which may impair shape fidelity. While the concept of good or poor printability seems rather intuitive, its quantitative definition lacks consensus and depends on multiple rheological and chemical parameters of the ink. This review discusses qualitative and quantitative methodologies to evaluate printability of bioinks for extrusion- and lithography-based bioprinting. The physicochemical parameters influencing shape fidelity are discussed, together with their importance in establishing new models, predictive tools and printing methods that are deemed instrumental for the design of next-generation bioinks, and for reproducible comparison of their structural performance.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- Chemical Reviews
- Topic
- 3D Printing in Biomedical Research
- Field
- Engineering
- Canadian institutions
- —
- Funders
- Nederlandse Organisatie voor Wetenschappelijk OnderzoekAO FoundationArthritis SocietyReumaNederlandDutch Arthritis Society
- Keywords
- 3D bioprintingNanotechnologyFidelityComputer scienceExtrusionLithography3D printingProcess (computing)Engineering drawingArtificial intelligenceMechanical engineeringMaterials scienceEngineeringTissue engineeringBiomedical engineering
- Has abstract in OpenAlex
- yes