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Record W3087632135 · doi:10.14740/jocmr4323

Low-Flow Nasal Cannula Hydrogen Therapy

2020· article· en· W3087632135 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

venuePublished in a venue whose home country is Canada.
no affNo Canadian affiliation: this work is invisible to an affiliation-only frame.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.

Bibliographic record

VenueJournal of Clinical Medicine Research · 2020
Typearticle
Languageen
FieldMedicine
TopicHydrogen's biological and therapeutic effects
Canadian institutionsnot available
Fundersnot available
KeywordsCannulaMedicineNasal cannulaAnesthesiaArterial bloodGas generatorInhalationBlood flowHydrogenBiomedical engineeringSurgeryChemistryInternal medicine

Abstract

fetched live from OpenAlex

Background: Molecular hydrogen (H 2 ) is a biologically active gas that is widely used in the healthcare sector. In recent years, on-site H 2 gas generators, which produce high-purity H 2 by water electrolysis, have begun to be introduced in hospitals, clinics, beauty salons, and fitness clubs because of their ease of use. In general, these generators produce H 2 at a low-flow rate, so physicians are concerned that an effective blood concentration of H 2 may not be ensured when the gas is delivered through a nasal cannula. Therefore, this study aimed to evaluate blood concentrations of H 2 delivered from an H 2 gas generator via a nasal cannula. Methods: We administered 100% H 2 , produced by an H 2 gas generator, at a low-flow rate of 250 mL/min via a nasal cannula to three spontaneously breathing micro miniature pigs. An oxygen mask was placed over the nasal cannula to administer oxygen while minimizing H 2 leakage, and a catheter was inserted into the carotid artery to monitor the arterial blood H 2 concentration. Results: During the first hour of H 2 inhalation, the mean (standard error (SE)) H 2 concentrations and saturations in the arterial blood of the three pigs were 1,560 (413) nL/mL and 8.85% (2.34%); 1,190 (102) nL/mL and 6.74% (0.58%); and 1,740 (181) nL/mL and 9.88% (1.03%), respectively. These values are comparable to the concentration one would expect if 100% of the H 2 released from the H 2 gas generator is taken up by the body. Conclusions: Inhalation of 100% H 2 produced by an H 2 gas generator, even at low-flow rates, can increase blood H 2 concentrations to levels that previous non-clinical and clinical studies demonstrated to be therapeutically effective. The combination of a nasal cannula and an oxygen mask is a convenient way to reduce H 2 leakage while maintaining oxygenation. J Clin Med Res. 2020;12(10):674-680 doi: https://doi.org/10.14740/jocmr4323

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.010
metaresearch head score (Gemma)0.011
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Research integrity, Insufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Other design · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.776
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0100.011
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.001
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.003
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.426
GPT teacher head0.560
Teacher spread0.134 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it