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Record W3107561667 · doi:10.18357/tar112202019612

Diet-Based Interventions Against Cancer

2020· article· en· W3107561667 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
venuePublished in a venue whose home country is Canada.

Bibliographic record

VenueThe Arbutus Review · 2020
Typearticle
Languageen
FieldMedicine
TopicDiet and metabolism studies
Canadian institutionsUniversity of Victoria
Fundersnot available
KeywordsMedicineHeadachesPsychological interventionClinical trialAdverse effectAdjuvantWeight lossConstipationCancerKetogenic dietInternal medicineCompliance (psychology)Physical therapySurgeryPsychiatryPsychologyEpilepsy

Abstract

fetched live from OpenAlex

Different diet-based approaches have been studied as potential adjuvants to standard cancer therapies in human clinical trials. However, these diets have been shown to have complications such as non-compliance and adverse side effects. This paper investigates four different types of diet-based approaches used in human clinical trials and compares their complications. The four diet-based approaches evaluated in this paper are ketogenic diet (KD), protein restriction, fasting and fasting mimicking diets (FMD), and combined interventions. Research shows that KDs have large reports of non-compliance from subjects, with subjects also experiencing significant weight loss, constipation, and fatigue. Protein restriction diets have greater levels of adherence from subjects but may lead to harmful hematological toxicities. Fasting and FMD showed greater adherence than subjects on KDs, and lower toxicities than subjects on protein restriction diets, but had a greater number of complaints of headaches, hunger, and dizziness. Finally, combined interventions have the fewest reports of side effects and non-compliance but suffer from a limited number of case studies. Given these results, diet-based interventions require further research to minimize side effects and non-compliance before becoming an accepted adjuvant to standard cancer therapy.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.522
Threshold uncertainty score0.398

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.116
GPT teacher head0.382
Teacher spread0.267 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it