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New Graph Embedding Approach for 3D Protein Shape Classification

2020· article· en· W3118976965 on OpenAlexaff
Kamel Madi

Bibliographic record

Venuenot available
Typearticle
Languageen
FieldComputer Science
TopicGraph Theory and Algorithms
Canadian institutionsNational Research Council Canada
Fundersnot available
KeywordsComputer scienceEmbeddingArtificial intelligenceGraphPattern recognition (psychology)Theoretical computer science

Abstract

fetched live from OpenAlex

We address the problem of 3D protein deformable shape classification. Proteins are macromolecules characterized by deformable and complex shapes which are related to their function making their classification an important task. Their molecular surface is represented by graphs such as triangular tessellations or meshes. In this paper, we propose a new graph embedding based approach for the classification of these 3D deformable objects. Our technique is based on graphs decomposition into a set of substructures, using triangle-stars, which are subsequently matched with the Hungarian algorithm. The proposed approach is based on an approximation of the Graph Edit Distance which is characterized by its robustness against both noise and distortion. Our algorithm defines a metric space using graph embedding techniques, where each object is represented by a set of selected 3D prototypes. We propose new approaches for prototypes selection and features reduction. The classification is performed with supervised machine learning techniques. The proposed method is evaluated against 3D protein benchmark repositories and state-of-the-art algorithms. Our experimental results consistently demonstrate the effectiveness of our approach.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.004
Threshold uncertainty score0.007

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.002
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0040.004
Science and technology studies0.0010.001
Scholarly communication0.0010.002
Open science0.0020.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0020.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.047
GPT teacher head0.260
Teacher spread0.214 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designSimulation or modeling
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations4
Published2020
Admission routes1
Has abstractyes

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