A multilayer multimodal detection and prediction model based on explainable artificial intelligence for Alzheimer’s disease

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Validation status

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Abstract

Alzheimer's disease (AD) is the most common type of dementia. Its diagnosis and progression detection have been intensively studied. Nevertheless, research studies often have little effect on clinical practice mainly due to the following reasons: (1) Most studies depend mainly on a single modality, especially neuroimaging; (2) diagnosis and progression detection are usually studied separately as two independent problems; and (3) current studies concentrate mainly on optimizing the performance of complex machine learning models, while disregarding their explainability. As a result, physicians struggle to interpret these models, and feel it is hard to trust them. In this paper, we carefully develop an accurate and interpretable AD diagnosis and progression detection model. This model provides physicians with accurate decisions along with a set of explanations for every decision. Specifically, the model integrates 11 modalities of 1048 subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI) real-world dataset: 294 cognitively normal, 254 stable mild cognitive impairment (MCI), 232 progressive MCI, and 268 AD. It is actually a two-layer model with random forest (RF) as classifier algorithm. In the first layer, the model carries out a multi-class classification for the early diagnosis of AD patients. In the second layer, the model applies binary classification to detect possible MCI-to-AD progression within three years from a baseline diagnosis. The performance of the model is optimized with key markers selected from a large set of biological and clinical measures. Regarding explainability, we provide, for each layer, global and instance-based explanations of the RF classifier by using the SHapley Additive exPlanations (SHAP) feature attribution framework. In addition, we implement 22 explainers based on decision trees and fuzzy rule-based systems to provide complementary justifications for every RF decision in each layer. Furthermore, these explanations are represented in natural language form to help physicians understand the predictions. The designed model achieves a cross-validation accuracy of 93.95% and an F1-score of 93.94% in the first layer, while it achieves a cross-validation accuracy of 87.08% and an F1-Score of 87.09% in the second layer. The resulting system is not only accurate, but also trustworthy, accountable, and medically applicable, thanks to the provided explanations which are broadly consistent with each other and with the AD medical literature. The proposed system can help to enhance the clinical understanding of AD diagnosis and progression processes by providing detailed insights into the effect of different modalities on the disease risk.

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The record

Venue

Scientific Reports

Topic

Machine Learning in Healthcare

Field

Computer Science

Canadian institutions

—

Funders

National Institute on AgingNational Institute of Biomedical Imaging and BioengineeringCanadian Institutes of Health ResearchGenentechNational Institutes of HealthIXICOH. Lundbeck A/SServierEisaiMeso Scale DiagnosticsNational Research Foundation of KoreaNational Research FoundationMinisterio de Ciencia, Innovación y UniversidadesNorthern California Institute for Research and EducationMinistry of Science and ICT, South KoreaPfizerBiogenBioClinicaF. Hoffmann-La RocheUniversity of Southern CaliforniaEuropean Regional Development FundMansoura UniversityEli Lilly and CompanyU.S. Department of DefenseAlzheimer's Disease Neuroimaging InitiativeNovartis Pharmaceuticals CorporationBristol-Myers SquibbAlzheimer's AssociationFoundation for the National Institutes of Health

Keywords

NeuroimagingArtificial intelligenceRandom forestComputer scienceClassifier (UML)DementiaMachine learningBinary classificationDiseaseCognitive impairmentModalitiesCognitionSet (abstract data type)PsychologyMedicinePsychiatryPathologySupport vector machine

Has abstract in OpenAlex

yes

API

/api/v1/works/W3125069671