On the string matching with <i>k</i> differences in DNA databases
Why this work is in the frame
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Bibliographic record
Abstract
In this paper, we discuss an efficient and effective index mechanism for the string matching with k differences, by which we will find all the substrings of a target string y of length n that align with a pattern string x of length m with not more than k insertions, deletions, and mismatches. A typical application is the searching of a DNA database, where the size of a genome sequence in the database is much larger than that of a pattern. For example, n is often on the order of millions or billions while m is just a hundred or a thousand. The main idea of our method is to transform y to a BWT-array as an index, denoted as BWT ( y ), and search x against it. The time complexity of our method is bounded by O( k · | T |), where T is a tree structure dynamically generated during a search of BWT ( y ). The average value of | T | is bounded by O(|Σ| 2 k ), where Σ is an alphabet from which we take symbols to make up target and pattern strings. This time complexity is better than previous strategies when k ≤ O(log |Σ| n ). The general working process consists of two steps. In the first step, x is decomposed into a series of l small subpatterns, and BWT ( y ) is utilized to speedup the process to figure out all the occurrences of such subpatterns with ⌊ k/l ⌋ differences. In the second step, all the found occurrences in the first step will be rechecked to see whether they really match x , but with k differences. Extensive experiments have been conducted, which show that our method for this problem is promising.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it