Application Value of Serum Hcy, TLR4, and CRP in the Diagnosis of Cerebral Small Vessel Disease
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A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
Post-publication record
- Nature
- Retraction
- Reason
- Compromised Peer Review;Investigation by Journal/Publisher;Investigation by Third Party;Paper Mill;Unreliable Results and/or Conclusions;
- Date
- 12/13/2023 0:00
- Flagged by OpenAlex?
- Yes
Source: Retraction Watch, joined by DOI. OpenAlex records retraction as is_retracted, a boolean over a state space with at least four values, so it cannot express an expression of concern, a correction or a reinstatement — it reports them as false, which reads as “fine”.
Abstract
Objective. To evaluate the application value of combined detection of serum homocysteine (Hcy), Toll-like receptor 4 (TLR4), and C-reactive protein (CRP) in the diagnosis of cerebral small vessel disease (CSVD). Methods. 90 patients with CSVD admitted to our hospital within the past year were identified as the research subjects, and the patients with cognitive dysfunction were assigned to the experimental group, and those with normal cognitive function were assigned to the control group according to the evaluation of cognitive dysfunction by the Montreal Cognitive Assessment (MoCA), with 45 cases in each group. Results. The experimental group obtained remarkably elevated Hcy levels than the control group <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" id="M1"> <a:mfenced open="(" close=")" separators="|"> <a:mrow> <a:mi>P</a:mi> <a:mo><</a:mo> <a:mn>0.05</a:mn> </a:mrow> </a:mfenced> </a:math> . The patient’s cognitive dysfunction is mainly attributed to the impact of serum Hcy. TLR4 and Hcy were negatively correlated with MoCA scores <f:math xmlns:f="http://www.w3.org/1998/Math/MathML" id="M2"> <f:mfenced open="(" close=")" separators="|"> <f:mrow> <f:mi>P</f:mi> <f:mo>></f:mo> <f:mn>0.05</f:mn> </f:mrow> </f:mfenced> </f:math> . In comparison with the control group, the experimental group had significantly higher levels of Hcy, serum CRP, and interleukin (IL)-6 <k:math xmlns:k="http://www.w3.org/1998/Math/MathML" id="M3"> <k:mfenced open="(" close=")" separators="|"> <k:mrow> <k:mi>P</k:mi> <k:mo><</k:mo> <k:mn>0.05</k:mn> </k:mrow> </k:mfenced> </k:math> . Conclusion. The combined detection of serum Hcy, TLR4, and CRP features a high clinical value in the diagnosis of CSVD, which contributes to the prevention and treatment of cognitive dysfunction in patients.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- Evidence-based Complementary and Alternative Medicine
- Topic
- Neurological Disease Mechanisms and Treatments
- Field
- Neuroscience
- Canadian institutions
- —
- Funders
- —
- Keywords
- HomocysteineMontreal Cognitive AssessmentMedicineInternal medicineDiseaseGastroenterologyCognitionTLR4C-reactive proteinCognitive impairmentInflammationPsychiatry
- Has abstract in OpenAlex
- yes