Childhood Abuse Is Associated with Methylation of Multiple Loci in Adult DNA
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Abuse in childhood, encompassing physical, sexual or emotional abuse, is a key component of a broader spectrum of child maltreatment [1]. Lifelong consequences of child abuse have been identified, including a greater risk of violence and delinquency, as well as adult depression and attempted suicide [1]. Hazardous behaviors, such as smoking and alcoholism, have also been found to be associated with abuse in childhood [2-4] along with later disease risk factors, including obesity [1,5], poorer immune function [1,6-8] earlier menarche [9-11] and outcomes such as ischemic heart disease [6,12,13] and chronic obstructive lung disease [13,14]. Explanations including biological mechanisms for long-term outcomes of child abuse have yet to be fully explored.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it