An Unexplored Diversity of Reverse Transcriptases in Bacteria
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Reverse transcriptase (RT) is generally considered a eukaryotic enzyme because it is prevalent in eukaryotes and was first characterized from eukaryotic sources. Discovered in 1970 in the Rous Sarcoma and murine leukemia viruses (1,2), RT has since been studied for its central role in the replication of many eukaryotic genetic elements including retroviruses (e.g., HIV-1), pararetroviruses, hepadnaviruses, long terminal repeat (LTR), and non-LTR retroelements, Penelope-like elements, and telomerase (3,4,5,6,7,8,9,10). Over the years, the accumulated studies of RT have painted a picture in which the enzyme functions primarily as the replicative enzyme of selfish DNAs (viruses, retrotransposons), while occasionally becoming domesticated to perform useful cellular functions. These functions include the maintenance of chromosomal ends (telomerase,DrosophilaHet-A elements) (10,11) and contributions to genomic change (both beneficial and deleterious) through pseudogene formation or other retroprocessing events (12,13,14,15).
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it