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Record W4250307082 · doi:10.1128/9781555819286.ch24

Intracellular Growth of Bacterial Pathogens: The Role of Secreted Effector Proteins in the Control of Phagocytosed Microorganisms

2016· book-chapter· en· W4250307082 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueASM Press eBooks · 2016
Typebook-chapter
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicVibrio bacteria research studies
Canadian institutionsUniversity of British Columbia
Fundersnot available
KeywordsEffectorIntracellularMicrobiologyMicroorganismIntracellular parasiteBacteriaBiologyCell biologyChemistryGenetics

Abstract

fetched live from OpenAlex

Of the 56 million deaths reported worldwide in 2012, approximately 15 million are directly related to infectious diseases (1). The majority of annual deaths are related to bacterial infections such as tuberculosis, yellow and typhoid fever, cholera, shigellosis, pneumonia, etc. (1). Morbidity and mortality rates are highest in developing countries, where large numbers of infants and children count among the victims (2). In developed nations, infectious disease mortality falls most heavily on indigenous and disadvantaged minorities (3). The control of bacterial infectious diseases worldwide is an important task. Although antibiotics revolutionized the treatment of bacterial infections, increased resistance and the emergence of multidrug-resistant strains increasingly reduce their efficacy. This trend promotes an urgent need for better understanding of bacterial pathogenicity and resistance mechanisms, which will assist novel therapeutic and vaccination strategies.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.161
Threshold uncertainty score0.737

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.009
GPT teacher head0.213
Teacher spread0.204 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it