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Record W4255984967 · doi:10.1385/1-59259-300-3:85

Spectral Karyotyping

2003· article· en· W4255984967 on OpenAlexaff
Jane Bayani, Jeremy A. Squire

Bibliographic record

VenueMolecular Cytogenetics · 2003
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenomic variations and chromosomal abnormalities
Canadian institutionsUniversity Health NetworkToronto Rehabilitation InstituteUniversity of TorontoOntario Institute for Cancer Research
Fundersnot available
KeywordsFluorescence in situ hybridizationBiologyKaryotypeCytogeneticsChromosomeIdentification (biology)Computational biologyGeneticsGeneBotany

Abstract

fetched live from OpenAlex

Historically in clinical cytogenetics, G-banding has been the gold standard for detecting gross chromosomal abnormalities, ranging from simple numerical changes to the identification of complex structural rearrangements in clinical samples. The designation “marker chromosome” or “derivative chromosome” has been used to indicate that G-banding has been unable to provide a definitive identification of the aberration. This is often because the complexity of the rearrangement has resulted in the lack of a coherent and recognizable banding pattern. The advent of the various multicolor fluorescence in situ hybridization (FISH) chromosomal painting techniques ( 1 , 1 ) has greatly improved our ability to identify all marker chromosomes, but these techniques still need some careful planning in rapidly achieving the goal of identifying complex chromosomal rearrangements. These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Methods · Consensus signal: Methods
Teacher disagreement score0.016
Threshold uncertainty score0.052

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0040.002
Science and technology studies0.0010.001
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0160.006

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.008
GPT teacher head0.216
Teacher spread0.208 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2003
Admission routes1
Has abstractyes

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