Prediction of Protein-Protein Interactions through Deep Learning Based on Sequence Feature Extraction and Interaction Network
Why this work is in the frame
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Bibliographic record
Abstract
Protein-protein interaction (PPI) is an important molecular process in the cell, which is vital to the function of the cell in the biochemical process. This study focuses on human protein. It uses protein information and the relationship of protein interaction network structure to predict PPI. Deep neural network model is implemented to realize PPI prediction. Through five-fold cross-validation, a high performance in the prediction accuracy is produced. The accuracy rate on the test set is 92.45%. To further evaluate the performance of this method, we compared it with other machine learning algorithms. The experimental results show that the method based on neural network is significantly better than the others on the same dataset. It also shows a superior performance compared to previous predictors in this field on PPI prediction.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it