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Record W4391723208 · doi:10.47197/retos.v53.102361

Efficacy and Effectiveness of Clinical Trials Applied to the Treatment of Obesity: A Systematic Review

2024· review· en· W4391723208 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueRetos · 2024
Typereview
Languageen
FieldMedicine
TopicPharmacology and Obesity Treatment
Canadian institutionsChildren's Hospital of Eastern Ontario
Fundersnot available
KeywordsClinical trialSystematic reviewMedicineIntensive care medicineObesityMEDLINEInternal medicinePolitical science

Abstract

fetched live from OpenAlex

The multidisciplinary treatment of obesity (MTO) has been recognized as the standard intervention and the basis for complementary treatments. However, it is still not clear how effective MTO programs can be and it has become more difficult to determine because normally the conditions of the intervention are not clearly stated. Therefore, it is important to make it clear if one MTO program is characterized as an efficacy trial, conducted under ideal conditions, or as an effectiveness trial developed in real-world scenarios. In this sense, this systematic review aims to explore some information from MTO studies. This systematic review made a search for potential papers using PubMed and SciELO, in which the terms efficacy or effectiveness were presented. After applying all the inclusion/exclusion criteria, four trials were included (343 participants). All the studies had characteristics of effectiveness trials. They used three different main outcomes, which made comparisons difficult. In conclusion, this review shows that a very small number of MTO studies have been published using the terminology efficacy or effectiveness. These studies do not explore the terms in a way that could make important distinctions among these distinct clinical trial models. Keywords: Obesity; Treatment; Efficacy; Effectiveness.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.007
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Systematic review · Consensus signal: Systematic review
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.137
Threshold uncertainty score0.786

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0070.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0110.001
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.252
GPT teacher head0.553
Teacher spread0.301 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it