Deformation of collagen-based tissues investigated using a systematic review and meta-analysis of synchrotron x-ray scattering studies
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Collagen fibrils are the building blocks of many tissues from fish scales and tendons to bone. Synchrotron small-angle X-ray scattering (SAXS) with in situ mechanical testing is a powerful tool to investigate collagen fibril deformation. There is a need to combine data from SAXS studies to investigate structure-function relationships. A literature search used the concepts of mechanical properties, collagen, and SAXS, with 52 articles meeting the eligibility criteria. Here, we report that mineralized tissues transfer a greater proportion of tissue-scale deformation to the fibril: 67% for cortical bone, 49% for tendon, 10% for ligament, and 3% for skin. Across non-mineralized tissues, tissues with less complexity and greater elastin content transfer less deformation to the fibril. The meta-analysis finds 20%–40% lower fibril strain in human aging and disease compared to controls, which contributes toward fracture risk. This synthesis demonstrates how variations in composition and structure tune material properties in collagen-based tissues.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.007 | 0.001 |
| Bibliometrics | 0.001 | 0.003 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it