Enhancing interpretability and accuracy of AI models in healthcare: a comprehensive review on challenges and future directions
Bibliographic record
Abstract
Artificial Intelligence (AI) has demonstrated exceptional performance in automating critical healthcare tasks, such as diagnostic imaging analysis and predictive modeling, often surpassing human capabilities. The integration of AI in healthcare promises substantial improvements in patient outcomes, including faster diagnosis and personalized treatment plans. However, AI models frequently lack interpretability, leading to significant challenges concerning their performance and generalizability across diverse patient populations. These opaque AI technologies raise serious patient safety concerns, as non-interpretable models can result in improper treatment decisions due to misinterpretations by healthcare providers. Our systematic review explores various AI applications in healthcare, focusing on the critical assessment of model interpretability and accuracy. We identify and elucidate the most significant limitations of current AI systems, such as the black-box nature of deep learning models and the variability in performance across different clinical settings. By addressing these challenges, our objective is to provide healthcare providers with well-informed strategies to develop innovative and safe AI solutions. This review aims to ensure that future AI implementations in healthcare not only enhance performance but also maintain transparency and patient safety.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.008 | 0.026 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.002 |
| Bibliometrics | 0.004 | 0.003 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.002 | 0.003 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".